CALCIUM D-GLUCARAT
200 mg/60 cps.
Calitate ultrapura
ANTI-CARCINOGEN, ANTI-TUMORAL, ANTI-METASTATIC, DETOXIFIANT
Calciul D-Glucarat este sarea calcică a Acidului D-Glucaric, o substanta produsa natural de catre mamifere inclusiv omul dar in cantitati extreme de mici. Este insa substanta care ajuta organismul sa elimine toxinele in special cele carcinogene. Suplimentarea pe cale orala cu Calciu D-Glucarat inhiba beta-glucuronidaza, o enzima produsa de microflora din colon si care este implictata in Faza II de detoxificare a ficatului. Prezenta in exces a beta-glucuronidazei este legata direct de riscurile marite pentru aparitia cancerelor cum ar fi la colon, sân, prostata, plămân, etc. O alta faţetă benefica a suplimentarii cu Calciu D-Glucarat este reglarea metabolismului estrogenului (in special la femei) si reducerea nivelului de lipide.
Pe scurt, Calciu D-Glucarat micsoreaza nivelul de glucuronidaza, si prin aceasta permite organismului sa elimine carcinogenii (substante chimice care cauzeaza cancer). Eliminarea carcinogenilor se face in special prin fecale, prin urmare este nevoie de un colon curat (nota: pentru curatirea colonului avem in farmacie produsul CURATITOR COLON)
In 1990, Walaszek (descoperitorul efectelor D-Glucaratului) s-a mutat la Centrul de Carcinogeneza MD Anderson din Houston, texas unde si-a continuat cercetarile. In mai multe articole publicate ulterior el arata ca Calciul D-Glucarat reduce “proliferatrea’ tumorilor, cu alte cuvinte prezenta ceastui agent le incetineste cresterea.
In 1991, 1992, 1993 si 1994 echipa Dr. Walaszek a efectuat mai multe teste atat pe animale cat si pe oameni demonstarnd ca doze mici de Calciu D-Glucarat administrate oral sunt convertite imediat in D-Glucaro-lactona care conduce la o activitate anti-tumorala marita a rentinoidelor. Pur si simplu, prin administrarea D-Glucaratului a fost imposibil sa se induca cancere prin metodele obisnuite de stimulare a cresterii tumorale
Tehnologia de extragere si purificare a Calciului D- Glucarat este patentata in Statele Unite.
Calciu D- Glucarat este parte integranta a protocolului nostru DETOXIN
COMPOZITIE:
Calciu D-Glucarat…………………200 mg
ADMINISTRARE: Adulti
1-2 capsule pe zi cu 30 minute inainte de mese.
Nu se recomanda gravidelor si lauzelor!
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BIBLIOGRAFIE:
1. Walaszek, Z., Hanausek, M., Szemraj, J., and Adams, A.K. 1998,
D-Glucarate acid as a prospective tumor marker. Meth. Mol. Med., 14,
487-495.
2. Walaszek, Z., Szemraj, J., Adams, A.K., and Hanausek, M. 1992,
Reduced levels of D-Glucaric acid in mammary tumor-bearing hosts and
the effect of its supplementation during estrogen replacement and tamoxifin
therapy. Proc. Am. Assoc. Cancer Res. 37: 183.
3. Heerdt, A.S., Young, C.W.., and Borgen, P.I., 1995, Calcium Glucarate
as a chemopreventative agent in breast cancer., Isr. J. Med. Sci. 31:
101-105.
4. Walaszek, Z. Chemopreventative properties of D-Glucaric acid
derivatives. Cancer Bull 1993; 45: 453-457.
5. Walaszek, Z., Szemraj, J., Adams, A.K., Kordari, P., and Hanausek, M.
1992, Reduced levels of D-Glucaric acid in mammary tumor-bearing Host.
Breast Cancer Res. Treat., 375: 108.
6. Walaszek, Z., Hanausek, M., Adams, A.K. and Sherman, U. 1991,
Cholesterol lowering effects of dietary D-Glucarate. Faseb J., 5: A930.
7. Walaszek, Z., Hanausek, M., Sherman, U. and Adams, A.K. 1990,
Antiproliferative effect of dietary glucarate on the Sprague Dawley in rat
mammary gland. Cancer Lett. 49: 51-57.
8. Walaszek, Z., Adams, A.K., Sherman, U., Viaje, A., Rotstein, J.B.,
Hanausek, M. and Slaga, T.J. 1990, Antiproliferate effects of Calcium
D-Glucarate (CG) and D-glucaro-1,4-lactone (GL) on the rat mammary
gland, colon and mouse skin. Proc. Am. Assoc. Cancer Res., 31: 124. p>
9. Walaszek, Z. 1990, Potential use of D-Glucarate acid derivatives in
cancer prevention. Cancer Lett. 54: 1-8.
10. DiGiovanni, J., 1990, Inhibition of chemical carcinogenesis. In:
Chemical Carcinogenesis and Mutagenesis II, Cooper, C.S. and Grover,
P.L. (eds.), Springer Verlag, Berlin, pp. 159-224.
11. Walaszek, Z., Adams, A.K., and Flores, F., 1989, Inhibition of
7,12-dimethylbenz(a)-anthracene(DMBA)-induced rat mammary
carcinogenesis by glucarate. Proc. Am. Assoc. Cancer Res., 30: 170.
12. Abbou-Issa, H., Koolemans-Beynen, A., Minton, J.P. and Webb, T.E.,
1989, Synergistic interaction between 13-cis-retinoic acid and glucarate:
activity against rat mammary tumor induction and MCF-7 cells. Biochem.
Biophys. Res. Commun.,163: 1364-1369.
13. Dwivedi, C., Oredipe, O.A., Barth, R.F., Downie, A.A. and Webb, T.E.,
1989, Effects of the experimental chemopreventative agent, glucarate on
intestinal carcinogenesis in rats. Carcinogenesis, 10: 1539-1541.
14. Oredipe, O.A., Barth, R.F., Dwivedi, C. and Webb, T.E., 1989,
Chemopreventative activity of dietary glucarate on azoxymethane-induced
altered hepatic loci in rats. Res. Commun. Chem. Pathol. Pharmacol., 65:
345-359.
15. Dwivedi. C., Downie, A.A. and Webb, T.E., 1989, Modulation of
chemically initiated and promoted skin tumorigenesis in CD-1 mice by
dietary glucarate. J. Environ. Path. Toxicol. Oncol., 9: 253-259.
16. Walaszek, Z., Hanausek, M., Sherman, U., Del Rio, M. and Adams,
A.K., 1989, Effects of (+) glucaric acid derivatives and tamoxifen on human
breast cancer cells (MCF-7). Breast Cancer Res. Treat., 14: 175.
17. Walaszek, Z., Flores, F. and Adams, A.K., 1988, Effect of dietary
glucarate on estrogen receptors and growth of 7,12-dimethylbenz[a]
anthracene-induced rat mammary carcinomas. Breast Cancer Res. Treat.,
12: 128.
18. Walaszek, Z., Hanausek-Walaszek, M. and Webb, T.E., 1988,
Repression by sustained release or glucuronidase inhibitors of chemical
carcinogen-mediated induction of a marker oncofetal protein in rodents. J.
Toxicol. Environ. Health, 23: 15-27.
19. Abbou-Issa, H.M., Duruibe, V.A., Minton, J.P., Larroya, S., Dwivedi,
C., and Webb, T.E., 1988, Putative metabolites derived from dietary
combinations of calcium glucarate and N-(4hydroxypheny)retinamide act
synergistically to inhibit the induction of rat mammary rumors by
7,12-dimethylbenz[a]-anthracene. Proc. Natl. Acad. Sci. USA. 85:
4181-4184.
20. Oredipe, O.A., Barth, R.F., Hanausek-Walaszek, M., Sautins, I.,
Walaszek, Z. and Webb, T.E. 1987, Effects of an inhibitor of
B-glucuronidase on hepatocarcinogenesis. Proc. Am. Assoc. Cancer Res.,
28: 156.
21. Oredipe, O.A., Barth, R.F., Hanausek-Walaszek, M., Sautins, I.
Walaszek, Z. and Webb, T.E. 1987, Effects of calcium glucarate on the
promotion of diethylnitrosamine-initiated altered hepatic loci in rats.
Cancer. Lett., 38, 95-99.
22. Walaszek, Z., Hanausek-Walaszek, M., Minton, J.P. and Webb, T.E.
1986, Dietary glucarate as antipromoter of
7,12-dimethylbenz[a]-anthra-cene-induced mammary tumorigenesis.
Carcinogenesis, 7:1463-1466.
23. Minton, J.P., Walaszek, Z., Hanausek-Walaszek, M., and Webb, T.E.
1986, B-Glucuronidase levels in patients with fibrocystic breast disease.
Breast Cancer Res. Treat., 8: 217-222.
24. Walaszek, Z., Hanausek-Walaszek, M., Webb, T.E., 1986, Dietary
glucarate-mediated reduction of sensitivity of murine strains to chemical to
chemical carcinogenesis. Cancer Lett., 33: 25-32.
